Concept Map
Primary Diagnosis: Parkinson’s
1. Describe the pathophysiology of the primary diagnosis in your own words. What are the
patient’s risk factors for this diagnosis?
Pathophysiology of Primary Diagnosis
The pathophysiology of Parkinson’s disease begins with the loss of dopaminergic neurons in
the SNpc. The studies involving families with Parkinson’s disease have led to a breakthrough
in the pathophysiology of this condition. According to Zafar and Yaddanapudi (2023), the
pathophysiology of Parkinson’s disease is associated with the accumulation of alpha-synuclein
in the various regions of the brain, particularly the substantial nigra, causing degeneration and
resulting dopamine loss in the basal ganglia that are responsible for controlling the muscle
movement and tone. This source recognizes that alpha-synuclein protein accumulation
operates as a factor secondary to
the genetic predisposition of a patient. Researchers have been drawn to examining an
infectious aetiology known to trigger this alpha syncline accumulation. Zafar and
Yaddanapudi (2023) contend that the knowledge about Parkinson’s disease is evolving. Thus,
it is imprudent to confine the aetiology of this condition to a lack of dopamine in the
substantia nigra. The pathophysiology of this condition appears to be broader and with the
implication of non-hereditary causes of alpha-synuclein deposition in the brain.
Causes Risk Factors (genetic/ethnic/physical)
The exact cause of Parkinson’s disease is
unknown. However, several factors are
known to contribute to the development of
There is a broad range of risk factors for
Parkinson’s disease, including age. This
condition is rarely experienced among young
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this condition. Genetics is the first factor.
Research studies have revealed specific
genetic complications that may cause
Parkinson’s disease (Bloem et al., 2021).
Although this cause is uncommon, it occurs
among patients with a family history of
Parkinson’s disease. Similarly, gene
variations elevate the risk of developing
Parkinson’s Disease.
Environmental triggers are also possible
causes of Parkinson’s disease. Exposure to
some toxins or environmental factors may
elevate the risk of later Parkinson’s disease
development. However, the risk is small.
adults. Its onset is majorly associated with
middle or late life. The risk of developing
Parkinson’s disease increases with increase in
age. Normally, this problem develops among
people aged 60 years or older. If a younger
person develops this condition, it is advisable
to seek genetic counselling to help in
decision-making in family planning.
The social conditions and side effects among
patients differ depending on age. Thus, these
factors require special consideration.
Genetics is another risk factor for Parkinson’s
disease. People with a family history of
Parkinson’s disease have higher odds of
developing this condition. The more relatives
with Parkinson’s disease a person has, the
higher the risk of developing this condition.
Sex is also a risk factor. Notably, men are
more likely to develop Parkinson’s disease
than their female counterparts.
Prolonged exposure to toxins, including
herbicides and pesticides, elevates the risk of
Parkinson’s disease.
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2. What are the patient’s signs and symptoms for this diagnosis? How does the diagnosis impact
other body systems and what are the possible complications?
Signs and Symptoms – Common presentation How does the diagnosis impact each body
system? Complications?
The signs and symptoms of Parkinson’s
disease are often expressed differently among
the patients. Early symptoms are expressed as
mild and may go unnoticed (Váradi, 2020).
Normally, the symptoms begin in one side of
the body and worsen on that side even after
the symptoms start expressing in limbs on
both sides. The common symptoms recorded
among patients with this condition include
tremors.
A tremor can be described as the rhythmic
shaking that normally occurs in a limb. The
patients may rub their thumb and forefinger
back and forth. Performing tasks alleviates
the shaking (Váradi, 2020). Another symptom
is slowed movement, scientifically termed
bradykinesia.
As the symptoms progress, the disease may
If ineffectively managed, Parkinson’s
Disease may cause cognitive problems
manifested as thinning difficulties. The
patients may experience complications,
including dementia (Gonzalez-Latapi et al.,
2021). These complications are uncommon
during the early stages of Parkinson’s disease.
Other possible complications that may occur
among the patients include depression and
emotional changes. Depression may develop
even during the early stages of the disease.
Employing interventions to address
depression may make it easy for the patients
to handle the other challenges associated with
Parkinson’s disease. The patients may
develop emotional damage, which is
expressed in the form of fear, anxiety and
reduced motivation. Patients may develop
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slow movement, making it difficult and time-
consuming for the patients to perform
common tasks. For instance, their steps may
become shorter when they walk. Secondly, it
may be challenging to get out of the chair.
Furthermore, one may shuffle their feet when
they walk. Patients may develop rigid
muscles.
Muscle stiffness can occur in any body part.
This symptom is followed by pain in the stiff
muscles and limited range of motion. The
patients experience impaired posture and
balance. Particularly, the posture becomes
stooped. These symptoms elevate the risk of
falls as the patients develop challenges with
balancing. Loss of automatic movement is
another possible symptom. The patients may
have reduced ability to perform unconscious
movements, including smiling, blinking, or
swinging their arms when they walk.
Changes in speech are also a possible
symptom of Parkinson’s Disease. The patient
may speak softly or quickly. Similarly, the
complications with swallowing. As the
condition progresses to later stages, saliva
may accumulate in the patient’s mouth due to
slowed swallowing, which may cause
drooling. Chewing and eating problems may
also occur during the last stages of the disease
as it impacts the muscles of the mouth. These
complications may lead to poor nutrition and
choking. Persons with Parkinson’s disease
may develop sleep problems, including
waking up frequently during the night or
waking up early. Rapid eye movement may
also occur. Bladder problems are another
complication that may occur among the
patients. The patient may develop difficulties
controlling urine or urinating. Constipation is
a problem of the gastrointestinal system that
may occur among patients having Parkinson’s
disease. This complication develops as a
result of a slower digestive tract.
Changes in blood pressure are a complication
that patients with Parkinson’s disease may
develop. The patients may feel lightheaded or
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patients may be hesitant before they talk.
Their speech may become a monotone instead
of their usual speech patterns. Changes in
writing are another key symptom of
Parkinson’s disease. Patients may experience
difficulty in writing as their writing may
appear small.
dizzy when they stand due to a sudden
reduction in blood pressure. Similarly, the
patients may experience problems with their
sense of smell. Specifically, they may have
trouble identifying some orders or differences
between odors . Sexual dysfunction is also
another problem patient with this condition
may develop. The patients may experience
reduced sexual desire or performance. Some
patients may experience pain either in the
whole body or in particular parts.
3. What are other potential diagnosis that present in a similar way to this diagnosis
(differentials)?
Differential diagnosis for Parkinson’s disease include a wide range of neurodegenerative
disorders and hereditary diseases including structural lesions, drugs or toxins, and metabolic
abnormalities.
These conditions include:
Alzheimer’s Disease
Lewy Body Dementia.
Essential Tremor.
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Cardioembolic Stroke.
4. What diagnostic tests or labs would you order to rule out the differentials for this patient or
confirm the primary diagnosis?
The following diagnostic tests can be utilized:
Magnetic resonance imaging of the brain (MRI brain).
A dopamine transporter scan (DaT scan).
Imaging of the brain (MRI brain).
Blood work.
5. What treatment options would you consider? Include possible referrals and medications.
Pharmacological
Levodopa: the first line pharmacological intervention for symptomatic treatment (Bogetofte et
al., 2020).
Monoamine oxidase (MAO)–B inhibitors: this treatment intervention is a suitable for early
disease.
Anticholinergic agents (eg, trihexyphenidyl, benztropine): the second-line treatment modality
for tremor only.
Referral:
Suppose the symptoms persist despite the treatment plan. In that case, the primary care
provider can refer the patient to a specialist, including a neurologist who specializes in
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managing conditions impacting the brain and nervous system. Geriatricians, as the name
suggests, specialize in conditions affecting older adults. Parkinson’s disease is a condition
uncommon among young people and hence falls under the geriatricians’ scope of practice.
References
Bloem, B. R., Okun, M. S., & Klein, C. (2021). Parkinson’s disease. The Lancet, 397(10291),
2284-2303. https://doi.org/10.1016/S0140-6736(21)00218-X
Bogetofte, H., Alamyar, A., Blaabjerg, M., & Meyer, M. (2020). Levodopa therapy for
Parkinson’s disease: history, current status and perspectives. CNS & Neurological
Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological
Disorders), 19(8), 572-583. https://doi.org/10.2174/1871527319666200722153156
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Gonzalez-Latapi, P., Bayram, E., Litvan, I., & Marras, C. (2021). Cognitive impairment in
Parkinson’s disease: epidemiology, clinical profile, protective and risk
factors. Behavioral Sciences, 11(5), 74, 2-22. https://doi.org/10.3390/bs11050074
Greenland, J. C., & Barker, R. A. (2018). The differential diagnosis of Parkinson’s disease. Exon
Publications, 109-128.
http://dx.doi.org/10.15586/codonpublications.parkinsonsdisease.2018.ch6
Kouli, A., Torsney, K. M., & Kuan, W. L. (2018). Parkinson’s disease: etiology, neuropathology,
and pathogenesis. Exon Publications, 3-26.
https://www.ncbi.nlm.nih.gov/books/NBK536722/#:~:text=Pathologically%2C%20the%
20movement%20disorder%20occurs,these%20may%20result%20in%20neurodegenerati
on.
Váradi, C. (2020). Clinical features of Parkinson’s disease: the evolution of critical
symptoms. Biology, 9(5), 103. https://doi.org/10.3390/biology9050103
Zafar, S., & Yaddanapudi, S. S. (2023). Parkinson disease. In StatPearls [Internet]. StatPearls
Publishing.